Andrew Prine guest-starred in Star Trek: The Next Generation's chilling episode "Frame of Mind," where he played Dr. Riker, a psychiatrist whose mysterious motives add layers to Commander Riker’s psychological unraveling. This episode remains a standout for fans of the series’ exploration of mind and identity, and Prine’s portrayal contributes significantly to its unsettling atmosphere. Though Prine's Star Trek work is not extensive, his presence in this memorable story places him alongside iconic cast members like Jonathan Frakes and under the direction of Corey Allen, whose vision shaped this psychological thriller. Fans of Prine may recall his wider career in film and television, including roles in westerns and dramatic features, but it is his part in “Frame of Mind” that connects him with the Star Trek universe. His portrayal gives the episode its eerie edge, making the blurred lines between reality and illusion truly compelling for viewers navigating the boundaries of the Star Trek experience.